PUBLICATIONS
FEATURED ARTICLES
FEATURED REVIEWS
Ghabrial, A., Luschnig, S., Metzstein, M. and Krasnow, M.A. (2003) Branching morphogenesis of the Drosophila tracheal system. Annual Review of Cell & Developmental Biology 19, 623-647. pdf
Lubarsky, B., and Krasnow, M.A. (2002)
Tube morphogenesis, making and shaping biological tubes. Cell 112, 19-28. pdf
Metzger, R. and Krasnow, M.A. (1999) Genetic control of branching morphogenesis. Science 284, 1635-1639. pdf
PUBLICATIONS
The Tabula Muris Consortium (2020) A single cell transcriptomic atlas characterizes aging tissues in the mouse. Nature, accepted. bioRxiv doi: https://doi.org/10.1101/661728.
Gillich, A., Fan Zhang, F. , Farmer, C.G., Gu, M., Zhou, B., Feinstein, J.A., Mark A. Krasnow, M.A.*, and Metzger, R.J.* (2020) Capillary cell type specialization in the alveolus revealed by single cell analysis. Submitted. (*, corresponding authors).
Travaglini, K.J., Nabhan, A.N., Penland, L., Sinha, R., Gillich, A., Sit, R.V., Chang, S., Conley, S.D., Mori, Y., Seita, J.,Berry, G.J., Shrager, J.B., Metzger, R.J., Kuo, C.S., Neff, N., Weissman, I.L., Quake, S.R.*, and Krasnow, M.A.* (2019) A molecular cell atlas of the human lung from single cell RNA sequencing. Submitted. bioRxivdoi: https://doi.org/10.1101/742320 (*, corresponding authors).
Bai, L., Mesgarzadeh, S., Ramesh, K.S., Huey, E.L., Liu, Y., Gray, L.A., Aitken, T.J., Chen, Y., Beutler, L.R., Ahn, J.S., Madisen, L., Zeng, H., Krasnow, M.A., and Knight, Z.A. (2019) Genetic identification of vagal sensory neurons that control feeding. Cell 179, 1129-1143.
Ouadah, Y., Rojas, E.R., Riordan, D.P., Capostagno, S, Kuo, C.S., and Krasnow, M.A. (2019) Rare pulmonary neuroendocrine cells are stem cells regulated by Rb, p53, and Notch. Cell 179, 403-416.
The Tabula Muris Consortium. (2018) Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562, 367-372. pdf
Travaglini, K.J. and Krasnow, M.A. (2018) Profile of an unknown airway cell. Nature 560, 313-314. pdf
Nabhan, N., Brownfield, D.G., Harbury, P.B., Krasnow, M.A.*, and Desai, T.J.*. (2018) Single cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Science, 359, 1118-1123 (*, corresponding authors).
Madelaine, R., Sloan, S.A., Huber, N., Notwell, J.H., Leung, L.C., Skariah, G., Halluin, C., Pasca, S.P., Bejerano, G., Krasnow, M.A., Barres, B.A., and Mourrain, P. (2017) micro-RNA-9 couples bain neurogenesis and angiogenesis. Cell Reports, 20, 1533-1542.
Ezran, C, Karanewsky, C.J., Pendleton, J.L., Sholtz, A., Krasnow, M.R., Willick J., Razafindrakoto, A., Zohdy, S., Albertelli, M., and Krasnow, M.A.(2017) Mouse lemur, a genetic model organism for primate biology, behavior, and health. Genetics, 206, 651-664 (Genetics Centennial Collection).
Yackle, K., Schwarz, L., Kam, K., Sorokin, J., Huguenard, J.R., Feldman, J.L., and Krasnow, M.A. (2017) Breathing control center neurons that promote arousal in mice. Science, 355, 1411-1415.
Tan, S.Y.S. and Krasnow, M.A. (2016) Developmental origin of lung macrophage diversity. Development 143, 1318-1327.
Li, P., Janczewski, W.A., Yackle, K., Kam, K., Pagliardini, S., Krasnow, M.A., and Feldman, J.L. (2016) The peptidergic control circuit of sighing. Nature, 530, 293-297.
Chang, A., Ortega, F., Riegler, J., Madison, D., and Krasnow, M.A.(2015) Oxygen control of breathing by an olfactory receptor activated by lactate. Nature, 527, 240-244.
Kuo, C. and Krasnow, M.A. (2015) Formation of a neurosensory organ by epithelial cell slithering. Cell, 163, 394-405.
Peterson, S.J. and Krasnow, M.A.(2015) Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle. Cell 160, 313-323.
Kumar, M.E., Bogard, P.E., Espinoza, F.H., Menke, D.B., Kingsley, D.M., Krasnow, M.A. (2014) Defining a mesenchymal progenitor niche at single cell resolution. Science 346, 1-9. pdf.
Martinez Alanis, D., Chang, D., Akiyama, H., Krasnow, M.A. and Chen, J.(2014) Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nature Communications 5 (3923), 1-15. pdf. Supplementary Info.
Treutlein, B.+, Brownfield, D.G.+, Wu, A.R., Neff, N.F., Mantalas, G.L., Espinoza, F.H., Desai, T.J.*, Krasnow, M.A.*, and Quake, S.R.* (2014) Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq. Nature 509, 371-375, (*, corresponding authors, +, co-first authors). pdf Extended Data. Supplementary Info.
Desai, T., Brownfield, D.G., and Krasnow, M.A. (2014) Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507, 190-194. pdf Extended Data. Supplementary Info.
Chen, F. and Krasnow, M.A. (2014) Progenitor outgrowth from the niche in Drosophila trachea is guided by FGF from decaying branches. Science 343, 186-189. pdf. Supplementary Info.
Desai, T. and Krasnow, M.A. (2013) Differentiated cells in a back-up role. Nature 503, 204-205. pdf
Tan, F., Vladar, E., Ma, L., Fuentealba, L., Hoh, R., Espinoza, F.H., Axelrod, J., Alvarez-Buylla, A., Stearns, T., Kintner, C. and Krasnow, M.A. (2013) The proto-oncogene Myb is expressed in post-mitotic epithelial cells and promotes centriole amplification and later steps of the multiciliogenesis program. Development 140, 4277-4286. pdf
Wang, H. St. Julien, K.R., Stevenson, D.K., Hoffmann, T.J., Witte, J.S., Lazzeroni, L.C., Krasnow, M.A., Quaintance, C.C., Oehlert, J.W., Jelliffe-Pawlowski, L., Gould, J.B., Shaw, G.M., and O’Brodovich, H.M. (2013) A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Pediatrics 132, 290-297. pdf
St. Julien, K., Jelliffe-Pawlowski, L.L., Shaw, G.M., Stevenson, D.K., O’Brodovich, H.M. and Krasnow, M.A. (2013) High quality genome-wide genotyping from archived dried blood spots without DNA amplification. PLoS One 8, e64710. pdf Supplementary info.
Chen, J. and Krasnow, M.A. (2012)
Integrin beta 1 suppresses multilayering of a simple epithelium. PLoS One 7, e52886.
Greif, D., Kumar, M, Lighthouse, J.K., Hum, J., An, A., Ding, L., Red-Horse, M.K., Espinoza, F.H., Olson, L., Offermanns, S., Krasnow, M.A. (2012)
Radial construction of an arterial wall. Dev Cell 23, 482-493.
Ghabrial, A.S., Levi, B.P. and Krasnow, M.A. (2011)
A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. PLoS Genetics 7: e1002087.
Red-Horse, K., Ueno, H., Weissman, I.L., Krasnow, M.A. (2010)
Coronary arteries form by developmental reprogramming of venous cells. Nature 464, 549-553.
London, N.R., Zhu, W., Bozza, F.A., Smith, M.C.P., Greif, D.M., Sorensen L.K., Chen, L., Kaminoh, Y., Chang, A.C., Passi, S.F., Day, C.W., Barnard, D.L., Zimmerman, G.A., Krasnow, M.A., Li, D.Y. (2010)
Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza. Science Trans Med 2, 1-9.
Weaver, M. and Krasnow, M.A. (2008)
Dual origin of tissue-specific progenitor cells in Drosophila tracheal remodeling. Science 321,1496.
Babcock, D.T., Fish, G., Wang, Y., Krasnow, M.A., and Galko, M.J. (2008) Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. PNAS 105, 10017-10022.
Metzger, R., Klein, O.D., Martin, G.R., and Krasnow, M.A. (2008)
The branching programme of mouse lung development. Nature 453, 745-750.
Metzstein, M.M. and Krasnow, M.A. (2006)
Functions of the nonsense-mediated RNA decay pathway in Drosophiladevelopment. PLoS Genetics 2, 2143-2154.
Ghabrial, A. and Krasnow, M.A. (2006)
Social interactions among epithelial cells during tracheal branching morphogenesis. Nature 441: 746-749. pdf
Levi, B., Ghabrial, A. and Krasnow, M.A. (2006)
Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization. Development 133: 2383-2393. pdf
Gerber, A.P., Luschnig, St., Krasnow, M.A., Brown, P.O., and Herschlag, D.(2006)
Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 103: 4487-4492. pdf
Jarvis, L., Toering, S., Simon, M., Krasnow, M.A., and Smith-Bolton, R.(2006)
Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. Development 133: 1133-1142. pdf
Luschnig, S., Batz, T., Armbruster, K., and Krasnow, M.A. (2006)
Serpentine and vermiform encode matrix proteins with chitin binding and deacetylation that limit tracheal tube length in Drosophila. Current Biology 16: 186-194. pdf
Devine, W.P., Lubarsky, B., Shaw, K., Luschnig, S., Messina, L., and Krasnow, M.A. (2005)
Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc. Natl. Acad. Sci. USA 102: 17014-17019. pdf
Galko, M. and Krasnow, M.A. (2004)
Cellular and genetic analysis of wound healing in Drosophila larvae. Public Library of Science Biology 2(8): e239, 1114-1126. pdf
Ghabrial, A., Luschnig, S., Metzstein, M. and Krasnow, M.A. (2003)
Branching morphogenesis of the Drosophila tracheal system. Annual Review of Cell & Developmental Biology 19, 623-647. pdf
Lubarsky, B., and Krasnow, M.A. (2002)
Tube morphogenesis: making and shaping biological tubes. Cell 112, 19-28. pdf
Arbeitman, M.N., Furlong, E.E., Imam, F., Johnson, E., Null, B.H., Baker, B.S., Krasnow, M.A., Scott, M.P., Davis, R.W., and White, K.P. (2002)
Gene expression during the life cycle of Drosophila melanogaster. Science 297, 2270-2275. pdf
Krasnow, M.A. and Nelson, W.J. (2002)
Tube morphogenesis. Trends in Cell Biology 12 (8), 351. pdf
Cho, N.K., Keyes, L., Johnson, E., Heller, J., Ryner, L., Karim, F., and Krasnow, M.A. (2002)
Developmental control of blood cell migration by the Drosophila VEGF pathway. Cell 108, 865-876. pdf
Shim, K., Blake, K., Jack, J. and Krasnow, M.A. (2001)
The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis. Development 128, 4923-4933. pdf
Guillemin, K., Williams, T., and Krasnow, M.A. (2001)
A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila. Nature Cell Biology 3, 848-851. pdf
Lee, S. H., Schloss, D.J., Jarvis, L., Krasnow, M.A., and Swain, J.L. (2001) Inhibition of angiogenesis by a mouse Sprouty protein. Journal of Biological Chemistry 276 (6), 4128-4133. pdf
Beitel, G. J. and Krasnow, M.A. (2000)
Genetic control of epithelial tube size in the Drosophila tracheal system. Development 127, 3271- 3282. pdf
Kornberg, T. B. and Krasnow, M.A. (2000)
The Drosophila genome sequence: Implications for biology and medicine. Science 287, 2218-2220. pdf
Jarecki, J., Johnson, E. and Krasnow, M.A. (1999)
Oxygen regulation of airway branching in Drosophila is mediated by Branchless FGF. Cell 99, 211-220 .pdf
Minowada, G., Jarvis, L.A., Chi, C.L., Neubüser, A. , Sun, X., Hacohen, N., Krasnow, M.A., and Martin, G.R. (1999)
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development 126, 4465-4475. pdf
Metzger, R. and Krasnow, M.A. (1999)
Genetic control of branching morphogenesis. Science 284, 1635-1639. pdf
Kramer, S., Okabe, M., Hacohen, N., Krasnow, M.A., and Hiromi, Y. (1999)
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 126, 2515-2525. pdf
Imam, F., Sutherland, D., Huang, W., and Krasnow, M.A. (1999)
Stumps, a Drosophila gene required for FGF-directed migrations of tracheal and mesodermal cells. Genetics 152, 307-318. pdf
Englund, C., Uv, A.E., Cantera, R., Mathies, L.D., Krasnow, M.A., and Samakovlis, C. (1999)
adrift, a novel bnl-induced Drosophila gene required for tracheal pathfinding into the CNS. Development 126(7):1505-14. pdf
Hacohen, N., Kramer, S. , Sutherland, D., Hiromi, Y, and Krasnow, M.A. (1998)
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263. pdf
Guillemin, K. and Krasnow, M.A. (1997)
The hypoxic response: Huffing and HIFing. Cell 89, 9-12. pdf
Sutherland, D., Samakovlis, C., and Krasnow, M.A. (1996)
Branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87, 1091-1101. pdf
Lee, T., Hacohen, N., Krasnow, M.A., and Montell, D.J. (1996)
Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes and Development 10, 2912-2921. pdf
Samakovlis, C., Manning, G., Hacohen, N. and Krasnow, M.A. (1996)
Genetic control of epithelial tube fusion during Drosophila tracheal development. Development 122, 3531-3526. pdf
Montagne, J., Groppe, J., Guillemin, K., Krasnow, M.A., Gehring, W.J., and Affolter, M. (1996)
The Drosophila serum response factor homolog is required for formation of intervein tissue of the wing and is allelic to blistered. Development 122, 2589-2597. pdf
Guillemin, K., Groppe, J., Ducker, K., Treisman, R., Hafen, E., Affolter, M., and Krasnow, M.A. (1996).
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development 122, 1353-1362. pdf
Samakovlis, C., Hacohen, N., Manning, G., Sutherland, D., Guillemin, K. and Krasnow, M.A. (1996).
Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development 122, 1395-1407. pdf
Van Gelder, R.N., and Krasnow, M.A. (1996).
Partners in time. Current Biology 6, 244-246. pdf
Van Gelder, R.N., Bae, H., Palazzolo, M.J., and Krasnow, M.A. (1995).
Extent and character of circadian gene expression in Drosophila melanogaster: identification of twenty oscillating mRNAs in the fly head. Current Biology 5, 1424-1436. pdf
Van Gelder, R.N., and Krasnow, M.A. (1996).
A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression. EMBO Journal 15, 1625-1631.
Johnson, F.B., Parker, E., and Krasnow, M.A. (1995).
Extradenticle protein is a selective cofactor for the Drosophila homeotics: Role of the homeodomain and YPWM amino acid motif in the interaction. Proc. Natl. Acad. Sci. USA 92, 739-743. pdf
Cumberledge, S. and Krasnow, M.A. (1994).
Preparation and analysis of pure cell populations from Drosophila. In Methods in Cell Biology, vol. 44 (Eds. E. Fyrberg and L. Goldstein), Academic Press, pp. 143-159. pdf
Saffman, E.E. and Krasnow, M.A. (1994).
A differential response element for the homeotics at the Antennapedia P1 promoter of Drosophila. Proc. Natl. Acad. Sci. USA 91, 7420-7424 .pdf
Manning, G. and Krasnow, M.A. (1993).
Development of the Drosophila tracheal system. In The Development of Drosophila melanogaster (Eds. M. Bate and A. Martinez Arias), Cold Spring Harbor Press (Cold Spring Harbor, New York), pp. 609-685.
Cumberledge, S. and Krasnow, M.A. (1993).
Intercellular signalling in Drosophila segment formation reconstructed in vitro. Nature 363, 549-52.
Johnson, F.B. and Krasnow, M.A. (1992).
Differential regulation of transcription preinitiation complex assembly by activator and repressor homeodomain proteins. Genes and Development 6, 2177-89. pdf
Krasnow, M.A., Cumberledge, S., Manning, G., Herzenberg, L. and Nolan, G. (1991).
Whole animal cell sorting of Drosophila embryos. Science 251, 81-85. pdf
Johnson, F.B. and Krasnow, M.A. (1990).
Stimulation of transcription by an Ultrabithorax protein in vitro. Genes and Development 4, 1044-52. pdf
Parker, E., Johnson, B., Saffman, E.E. and Krasnow, M.A. (1989). Transcriptional regulation by homeotic gene products in cultured Drosophila cells and in vitro. In Current Communications in Molecular Biology, Cold Spring Harbor Press (Cold Spring Harbor, New York), pp.23-29.
Winslow, G.M., Hayashi, S., Krasnow, M., Hogness, D.S. and Scott, M.P. (1989).
Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells. Cell 57, 1017-30. pdf
Krasnow, M.A., Saffman, E.E., Kornfeld, K. and Hogness, D.S. (1989). Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells. Cell 57, 1031-43. pdf
Beachy, P.A., Krasnow, M.A., Gavis, E.R., and Hogness, D.S. (1988).
An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters. Cell 55, 1069-81.
Benjamin, H., Matzuk, M., Krasnow, M.A. and Cozzarelli, N.R. (1985). Recombination site selection by Tn3 resolvase: Topological tests of a tracking mechanism. Cell 40, 147-58.
Cozzarelli, N.R., Krasnow, M.A., Gerrard, S.B., and White, J.H. (1984).
A topological treatment of recombination and topoisomerases. Cold Spring Harbor Symposia on Quantitative Biology XLIX, 383-400.
Krasnow, M.A., Stasiak, A., Spengler, S.J., Dean, F., Koller, T., and Cozzarelli, N.R. (1983).
Determination of the absolute handedness of knots and catenanes of DNA. Nature 304, 559-560.
Krasnow, M.A., Matzuk, M.M., Dugan, J.M., Benjamin, H.W. and Cozzarelli, N.R. (1983).
Site-specific recombination by Tn3 resolvase: models for pairing of recombination sites. In Mechanisms of DNA Replication and Recombination. UCLA Symposia on Molecular and Cellular Biology, New Series Volume X, ed. Nicholas R. Cozzarelli, Alan R. Liss, Inc. (New York, NY), pp. 637-659.
Dean, F., Krasnow, M.A., Otter, R., Matzuk, M.M., Spengler, S.J., and Cozzarelli, N.R. (1983).
Escherichia coli type 1 topoisomerases: identification, mechanisms, and role in recombination. Cold Spring Harbor Symposia on Quantitative Biology XLVII, 769-777.
Krasnow, M.A. and Cozzarelli, N.R. (1983).
Site-specific relaxation and recombination by the Tn3 resolvase: recognition of the DNA path between oriented res sites. Cell 32, 1313-1324.
Krasnow, M.A. and Cozzarelli, N.R. (1982).
Catenation of DNA rings by topoisomerases: mechanism of control by spermidine. Journal of Biological Chemistry 257, 2687-2693 .pdf.